Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 4/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | CFTR | P13569 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | TSPO | P30536 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA5A | P35218 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL914622 | 0.87 | ALDH1A1 (0.51) | ALDH1A1LMNATSHRHSD17B10CFTR | |
| SCHEMBL915283 | 0.86 | ALDH1A1 (0.57) | ALDH1A1LMNATSHRHSD17B10CFTR | |
| SCHEMBL6575682 | 0.81 | TSHR (0.46) | ALDH1A1LMNATSHRKMT2APOLB | |
| SCHEMBL915965 | 0.81 | ALDH1A1 (0.51) | ALDH1A1LMNATSHRHSD17B10CFTR | |
| SCHEMBL9265394 | 0.80 | HPGD (0.41) | ALDH1A1LMNATSHRHIF1AKDM4E | |
| SCHEMBL9022038 | 0.80 | HPGD (0.41) | ALDH1A1LMNATSHRHIF1AKDM4E | |
| SCHEMBL70322 | 0.80 | ALDH1A1 (0.66) | ALDH1A1LMNATSHRHSD17B10CFTR | |
| SCHEMBL156281 | 0.80 | ALDH1A1 (0.66) | ALDH1A1LMNATSHRHSD17B10CFTR | |
| SCHEMBL10360804 | 0.80 | ALDH1A1 (0.77) | ALDH1A1LMNATSHRHSD17B10CFTR | |
| SCHEMBL10610893 | 0.79 | TSHR (0.42) | ALDH1A1LMNATSHRKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3055293-A1 | DIARYLALKYLAMINE REV-ERB ANTAGONISTS AND THEIR USE AS MEDICAMENTS | Fondazione Istituto Italiano di Tecnologia (IT) | 2016-08-17 | — | — | EP | disclosed |
| WO-2015052283-A1 | DIARYLALKYLAMINE REV-ERB ANTAGONISTS AND THEIR USE AS MEDICAMENTS | FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA (IT) | 2015-04-16 | — | — | WO | disclosed |
| EP-1706379-A1 | DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF | AstraZeneca AB (SE) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005066127-A1 | DIARYLMETHYLIDENE PIPERIDINE DERIVATIVES, PREPARATIONS THEREOF AND USES THEREOF | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | WO | disclosed |