Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.49 |
| ▸ | PGR | P06401 | 4/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5127973 | 0.85 | SLC6A2 (0.52) | SLC6A2SLC6A4PGRCYP2D6CYP2C9 | |
| SCHEMBL28942626 | 0.85 | SLC6A2 (0.52) | SLC6A2SLC6A4PGRCYP2D6CYP2C9 | |
| SCHEMBL5120703 | 0.83 | SLC6A2 (0.60) | SLC6A2SLC6A4PGRCYP2D6CYP2C9 | |
| SCHEMBL5695889 | 0.81 | KDM4E (0.45) | PGRCYP2D6CYP2C9KDM4EALDH1A1 | |
| SCHEMBL5670810 | 0.77 | SLC6A2 (0.53) | SLC6A2SLC6A4PGRCYP2D6CYP2C9 | |
| SCHEMBL27661559 | 0.77 | SLC6A2 (0.53) | SLC6A2SLC6A4PGRCYP2D6CYP2C9 | |
| SCHEMBL5996568 | 0.76 | SLC6A2 (0.55) | SLC6A2SLC6A4PGRCYP2D6CYP2C9 | |
| SCHEMBL5127330 | 0.75 | SLC6A2 (0.59) | SLC6A2SLC6A4PGRCYP2D6CYP2C9 | |
| SCHEMBL3652853 | 0.72 | EPHX2 (0.57) | CYP2C9 | |
| SCHEMBL5734230 | 0.70 | SLC6A2 (0.51) | SLC6A2SLC6A4PGRCYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660064-A2 | TREATMENT OF LEARNING DISABILITIES AND MOTOR SKILLS DISORDER WITH NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005020975-A2 | TREATMENT OF LEARNING DISABILITIES AND MOTOR SKILLS DISORDER WITH NOREPINEPHRINE REUPTAKE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-03-10 | — | — | WO | disclosed |