SCHEMBL5994181

SCHEMBL5994181

Cc1cccc(Cl)c1C(=S)C(C)P

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.39
TYK2 P29597 1/20 0.39
UTS2R Q9UKP6 1/20 0.36
ALDH1A1 P00352 4/20 0.35
NPSR1 Q6W5P4 1/20 0.35
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
ITGB1 P05556 3/20 0.33
ITGA4 P13612 3/20 0.33
KDM4E B2RXH2 1/20 0.33
ITGA2 P17301 1/20 0.33
ITGB7 P26010 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
MAPT P10636 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
FABP3 P05413 1/20 0.33
FABP4 P15090 1/20 0.33
LMNA P02545 1/20 0.33
DRD3 P35462 1/20 0.32
PDK1 Q15118 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5997947 0.79 TYK2 (0.45) TYK2UTS2RALDH1A1KMT2AITGB1
SCHEMBL5994666 0.76 UTS2R (0.38) GAATYK2UTS2RALDH1A1NPSR1
SCHEMBL11851293 0.75 GAA (0.44) GAATYK2ALDH1A1NPSR1MEN1
SCHEMBL11844218 0.73 ALDH1A1 (0.51) GAATYK2ALDH1A1NPSR1MEN1
SCHEMBL16884653 0.70 TYK2 (0.47) TYK2UTS2RALDH1A1KMT2AITGB1
SCHEMBL5994177 0.70 GAA (0.38) GAATYK2UTS2RALDH1A1NPSR1
SCHEMBL5994785 0.70 ALDH1A1 (0.38) GAATYK2UTS2RALDH1A1NPSR1
SCHEMBL2722565 0.70 TYK2 (0.46) GAATYK2UTS2RALDH1A1KMT2A
SCHEMBL5996817 0.69 ALDH1A1 (0.50) GAATYK2ALDH1A1
SCHEMBL5995137 0.69 UTS2R (0.43) TYK2UTS2RALDH1A1ITGB1ITGA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7109250-B2 Multimer forms of acylphosphines and their derivatives CIBA SPECIALTY CHEMICALS CORP. (US) 2006-09-19 US disclosed
US-7026017-B2 Photoinitiators for acrylic esters; reacting an acyl halide with a metal benzoyl phosphine; cable coatings, screen printing stencils, resist materials, colour filters, electrical encapsulation CIBA SPECIALTY CHEMICALS CORPORATION (US) 2006-04-11 US disclosed
US-6969733-B2 Photoinitiators CIBA SPECIALTY CHEMICALS CORPORATION (US) 2005-11-29 US disclosed
US-20050004247-A1 Multimer forms of acylphosphines and their derivatives CIBA SPECIALTY CHEMICALS CORP. 2005-01-06 US disclosed
EP-1446410-A1 MULTIMER FORMS OF ACYLPHOSPHINES AND THEIR DERIVATIVES Ciba SC Holding AG (CH) 2004-08-18 EP disclosed
US-6737549-B2 PHOTOINITIATORS FOR ACRYLATE COATINGS CIBA SPECIALTY CHEMICALS CORPORATION 2004-05-18 US disclosed
US-20030139485-A1 Photoinitiators WOLF JEAN-PIERRE (CH) 2003-07-24 US disclosed
US-20030130370-A1 Photoinitiators for acrylic esters; reacting an acyl halide with a metal benzoyl phosphine; cable coatings, screen printing stencils, resist materials, colour filters, electrical encapsulation WOLF JEAN-PIERRE (CH) 2003-07-10 US disclosed
WO-2003044030-A1 MULTIMER FORMS OF ACYLPHOSPHINES AND THEIR DERIVATIVES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-05-30 WO disclosed
US-20020026049-A1 Photoinitiators for acrylate coatings CIBA SPECIALTY CHEMICALS CORP. 2002-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030139485-A1 Photoinitiators DHCR24, NR1I3, CBR1 GAA 4801/4885TYK2 2818/4885UTS2R 2725/4885
US-20030130370-A1 Photoinitiators for acrylic esters; reacting an acyl halide with a metal benzoyl phosphine; cable coatings, screen printing stencils, resist materials, colour filters, electrical encapsulation SMARCC1, ARPC5L, DHCR24 GAA 4108/4885TYK2 3482/4885UTS2R 2574/4885
US-20020026049-A1 Photoinitiators for acrylate coatings DHCR24, NR5A1, NR2C2 GAA 4741/4885TYK2 2581/4885UTS2R 2430/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.