SCHEMBL5995441

SCHEMBL5995441

Cc1cccc(-c2ccccc2)c1C(=O)PCC(C)C

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.40
L3MBTL1 Q9Y468 4/20 0.39
FOLH1 Q04609 1/20 0.38
LMNA P02545 5/20 0.38
SMN1; SMN2 Q16637 4/20 0.38
MEN1 O00255 1/20 0.38
ALDH1A1 P00352 3/20 0.37
KDM4E B2RXH2 2/20 0.37
PDCD1 Q15116 1/20 0.37
CD274 Q9NZQ7 1/20 0.37
FABP3 P05413 1/20 0.36
FABP4 P15090 1/20 0.36
MYC P01106 1/20 0.36
CYP46A1 Q9Y6A2 1/20 0.36
NPSR1 Q6W5P4 3/20 0.36
NPC1 O15118 1/20 0.36
MAPT P10636 1/20 0.36
RAB9A P51151 1/20 0.36
PPARG P37231 1/20 0.36
PPARA Q07869 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27487724 0.99 KMT2A (0.39) KMT2AL3MBTL1FOLH1LMNASMN1; SMN2
SCHEMBL5997139 0.85 L3MBTL1 (0.36) KMT2AL3MBTL1SMN1; SMN2MEN1ALDH1A1
SCHEMBL5997513 0.84 KMT2A (0.35) KMT2AL3MBTL1FOLH1LMNASMN1; SMN2
SCHEMBL5996026 0.84 FOLH1 (0.44) KMT2AL3MBTL1FOLH1LMNASMN1; SMN2
SCHEMBL27487363 0.82 FOLH1 (0.43) KMT2AL3MBTL1FOLH1LMNASMN1; SMN2
SCHEMBL5996400 0.79 KMT2A (0.39) KMT2AL3MBTL1FOLH1LMNASMN1; SMN2
SCHEMBL5994307 0.79 SOAT1 (0.40) KMT2AL3MBTL1FOLH1SMN1; SMN2ALDH1A1
SCHEMBL5996981 0.78 TYK2 (0.41) ALDH1A1FABP3FABP4
SCHEMBL27487732 0.77 TYK2 (0.40) ALDH1A1FABP3FABP4
SCHEMBL7181842 0.75 MYC (0.39) KMT2AL3MBTL1FOLH1LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7109250-B2 Multimer forms of acylphosphines and their derivatives CIBA SPECIALTY CHEMICALS CORP. (US) 2006-09-19 US disclosed
US-7026017-B2 Photoinitiators for acrylic esters; reacting an acyl halide with a metal benzoyl phosphine; cable coatings, screen printing stencils, resist materials, colour filters, electrical encapsulation CIBA SPECIALTY CHEMICALS CORPORATION (US) 2006-04-11 US disclosed
US-6969733-B2 Photoinitiators CIBA SPECIALTY CHEMICALS CORPORATION (US) 2005-11-29 US disclosed
US-20050004247-A1 Multimer forms of acylphosphines and their derivatives CIBA SPECIALTY CHEMICALS CORP. 2005-01-06 US disclosed
EP-1446410-A1 MULTIMER FORMS OF ACYLPHOSPHINES AND THEIR DERIVATIVES Ciba SC Holding AG (CH) 2004-08-18 EP disclosed
US-6737549-B2 PHOTOINITIATORS FOR ACRYLATE COATINGS CIBA SPECIALTY CHEMICALS CORPORATION 2004-05-18 US disclosed
US-20030139485-A1 Photoinitiators WOLF JEAN-PIERRE (CH) 2003-07-24 US disclosed
US-20030130370-A1 Photoinitiators for acrylic esters; reacting an acyl halide with a metal benzoyl phosphine; cable coatings, screen printing stencils, resist materials, colour filters, electrical encapsulation WOLF JEAN-PIERRE (CH) 2003-07-10 US disclosed
WO-2003044030-A1 MULTIMER FORMS OF ACYLPHOSPHINES AND THEIR DERIVATIVES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-05-30 WO disclosed
US-20020026049-A1 Photoinitiators for acrylate coatings CIBA SPECIALTY CHEMICALS CORP. 2002-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030139485-A1 Photoinitiators DHCR24, NR1I3, CBR1 KMT2A 1784/4885L3MBTL1 1852/4885FOLH1 4665/4885
US-20030130370-A1 Photoinitiators for acrylic esters; reacting an acyl halide with a metal benzoyl phosphine; cable coatings, screen printing stencils, resist materials, colour filters, electrical encapsulation SMARCC1, ARPC5L, DHCR24 KMT2A 761/4885L3MBTL1 1879/4885FOLH1 4856/4885
US-20020026049-A1 Photoinitiators for acrylate coatings DHCR24, NR5A1, NR2C2 KMT2A 1577/4885L3MBTL1 2570/4885FOLH1 4769/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.