Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | GSK3A | P49840 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL991479 | 0.67 | MAPT (0.46) | TTKMAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL27842477 | 0.59 | MEN1 (0.48) | MAPTMEN1KMT2AALDH1A1HTT | |
| SCHEMBL28799465 | 0.59 | KAT2B (0.55) | MAPTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL8128287 | 0.59 | MAPT (0.39) | MAPTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL1772257 | 0.58 | TDP1 (0.55) | MAPTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL9771684 | 0.58 | MAPT (0.54) | MAPTMEN1KMT2AALDH1A1HTT | |
| SCHEMBL6218914 | 0.58 | MAPT (0.41) | MAPTMEN1KMT2AALDH1A1CYP1A2 | |
| SCHEMBL8236017 | 0.57 | KDM4E (0.41) | ALDH1A1POLBATMKDM4EHPGD | |
| SCHEMBL29901090 | 0.57 | KAT2B (0.60) | MAPTMEN1KMT2AALDH1A1POLB | |
| SCHEMBL31533512 | 0.57 | MEN1 (0.44) | MAPTMEN1KMT2AALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1720862-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005080380-A1 | KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2005-09-01 | — | — | WO | disclosed |