SCHEMBL5997944

SCHEMBL5997944

Cc1cccc(Cl)c1C(=O)CCP

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYK2 P29597 1/20 0.44
ALDH1A1 P00352 2/20 0.42
FEN1 P39748 1/20 0.42
UTS2R Q9UKP6 1/20 0.39
FABP3 P05413 1/20 0.38
FABP4 P15090 1/20 0.38
ITGB1 P05556 2/20 0.38
ITGA4 P13612 2/20 0.38
ITGA2 P17301 1/20 0.38
ITGB7 P26010 1/20 0.38
TRPM4 Q8TD43 1/20 0.37
ALDH2 P05091 1/20 0.36
ELANE P08246 1/20 0.36
HCRTR1 O43613 1/20 0.36
HCRTR2 O43614 1/20 0.36
HPGD P15428 1/20 0.36
KMT2A Q03164 2/20 0.35
MEN1 O00255 1/20 0.35
PTGS2 P35354 1/20 0.35
AKR1B1 P15121 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5996812 0.87 FEN1 (0.53) TYK2ALDH1A1FEN1HPGDKMT2A
SCHEMBL5994212 0.87 F2R (0.38) ALDH1A1FEN1HPGDKMT2AMEN1
SCHEMBL5995137 0.81 UTS2R (0.43) TYK2ALDH1A1FEN1UTS2RFABP3
SCHEMBL9720600 0.80 TYK2 (0.47) TYK2ALDH1A1FEN1UTS2RFABP3
SCHEMBL27489116 0.80 UTS2R (0.43) TYK2ALDH1A1FEN1UTS2RFABP3
SCHEMBL5997559 0.79 ALDH1A1 (0.41) ALDH1A1FEN1KMT2AMEN1PTGS2
SCHEMBL5994177 0.79 GAA (0.38) TYK2ALDH1A1FEN1UTS2RFABP3
SCHEMBL5994816 0.79 CA12 (0.47) ALDH1A1FEN1FABP4ITGB1ITGA4
SCHEMBL5996031 0.76 FOLH1 (0.41) ALDH1A1KMT2ARAB9A
SCHEMBL27614436 0.75 MAPT (0.46) ALDH1A1KMT2AMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7109250-B2 Multimer forms of acylphosphines and their derivatives CIBA SPECIALTY CHEMICALS CORP. (US) 2006-09-19 US disclosed
US-7026017-B2 Photoinitiators for acrylic esters; reacting an acyl halide with a metal benzoyl phosphine; cable coatings, screen printing stencils, resist materials, colour filters, electrical encapsulation CIBA SPECIALTY CHEMICALS CORPORATION (US) 2006-04-11 US disclosed
US-6969733-B2 Photoinitiators CIBA SPECIALTY CHEMICALS CORPORATION (US) 2005-11-29 US disclosed
US-20050004247-A1 Multimer forms of acylphosphines and their derivatives CIBA SPECIALTY CHEMICALS CORP. 2005-01-06 US disclosed
EP-1446410-A1 MULTIMER FORMS OF ACYLPHOSPHINES AND THEIR DERIVATIVES Ciba SC Holding AG (CH) 2004-08-18 EP disclosed
US-6737549-B2 PHOTOINITIATORS FOR ACRYLATE COATINGS CIBA SPECIALTY CHEMICALS CORPORATION 2004-05-18 US disclosed
US-20030139485-A1 Photoinitiators WOLF JEAN-PIERRE (CH) 2003-07-24 US disclosed
US-20030130370-A1 Photoinitiators for acrylic esters; reacting an acyl halide with a metal benzoyl phosphine; cable coatings, screen printing stencils, resist materials, colour filters, electrical encapsulation WOLF JEAN-PIERRE (CH) 2003-07-10 US disclosed
WO-2003044030-A1 MULTIMER FORMS OF ACYLPHOSPHINES AND THEIR DERIVATIVES CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) 2003-05-30 WO disclosed
US-20020026049-A1 Photoinitiators for acrylate coatings CIBA SPECIALTY CHEMICALS CORP. 2002-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030139485-A1 Photoinitiators DHCR24, NR1I3, CBR1 TYK2 2818/4885ALDH1A1 974/4885FEN1 3857/4885
US-20030130370-A1 Photoinitiators for acrylic esters; reacting an acyl halide with a metal benzoyl phosphine; cable coatings, screen printing stencils, resist materials, colour filters, electrical encapsulation SMARCC1, ARPC5L, DHCR24 TYK2 3482/4885ALDH1A1 1088/4885FEN1 4789/4885
US-20020026049-A1 Photoinitiators for acrylate coatings DHCR24, NR5A1, NR2C2 TYK2 2581/4885ALDH1A1 835/4885FEN1 4113/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.