SCHEMBL599845

SCHEMBL599845

O=C(c1ccccc1)n1c(=O)[nH]cc(F)c1=O

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TYMP P19971 1/20 0.45
KMT2A Q03164 2/20 0.44
P2RX4 Q99571 1/20 0.44
IDO1 P14902 1/20 0.41
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
MEN1 O00255 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
SRC P12931 1/20 0.39
KDM4E B2RXH2 2/20 0.39
ALOX15 P16050 1/20 0.39
SIGMAR1 Q99720 1/20 0.38
GSK3A P49840 1/20 0.38
GSK3B P49841 1/20 0.38
ELANE P08246 1/20 0.37
LMNA P02545 1/20 0.36
POLB P06746 1/20 0.36
NOD1 Q9Y239 1/20 0.36
CES1 P23141 1/20 0.36
CDK2 P24941 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2189433 0.80 TYMP (0.53) TYMPKMT2AP2RX4IDO1NPC1
SCHEMBL2745392 0.80 TYMP (0.45) TYMPKMT2AP2RX4IDO1NPC1
SCHEMBL28562422 0.76 TYMP (0.46) TYMPKMT2AP2RX4IDO1NPC1
SCHEMBL16632478 0.74 TYMP (0.43) TYMPKMT2AP2RX4IDO1NPC1
SCHEMBL3015728 0.72 TYMP (0.54) TYMPKMT2AP2RX4IDO1NPC1
SCHEMBL11631449 0.72 KMT2A (0.55) TYMPKMT2AP2RX4IDO1NPC1
SCHEMBL14491 0.70 TYMP (0.49) TYMPKMT2AP2RX4IDO1NPC1
SCHEMBL11792243 0.69 P2RX4 (0.59) TYMPKMT2AP2RX4IDO1NPC1
SCHEMBL31621004 0.69 TYMP (0.60) TYMPKMT2AP2RX4IDO1NPC1
SCHEMBL2892389 0.68 TYMP (0.43) TYMPKMT2AP2RX4IDO1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4598923-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS The Regents of the University of California (US) 2025-08-13 EP disclosed
US-20240197682-A1 METHOD FOR TREATING NEUROLOGICAL DISEASES USING SUPRAMOLECULE POLYMER THERAPEUTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 US disclosed
US-20240199604-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 US disclosed
US-20240201205-A1 METHOD FOR DETECTING NEUROLOGICAL DISEASES USING SUPRAMOLECULE POLYMER THERAPEUTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-06-20 US disclosed
WO-2024059845-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2024-03-21 WO disclosed
US-20230357168-A1 CARBOBICYCLIC NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTION UNIV HONG KONG CHINESE (CN) 2023-11-09 US disclosed
US-20170218001-A1 PHOSPHONATE NUCLEOSIDES USEFUL IN THE TREATMENT OF VIRAL DISEASES KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2017-08-03 US disclosed
US-20170218001-A1 PHOSPHONATE NUCLEOSIDES USEFUL IN THE TREATMENT OF VIRAL DISEASES KATHOLIEKE UNIVERSITEIT LEUVEN (BE) 2017-08-03 US disclosed
WO-2015177351-A1 PHOSPHONATE NUCLEOSIDES USEFUL IN THE TREATMENT OF VIRAL DISEASES UNIVERSITY COLLEGE CORK (IE) 2015-11-26 WO disclosed
US-8114994-B2 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment viral infections and abnormal cellular proliferation EMORY UNIVERSITY (US) 2012-02-14 US disclosed
US-7495006-B2 2′ and 3′-substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation EMORY UNIVERSITY (US) 2009-02-24 US disclosed
EP-1828145-A2 2' AND 3' - SUBSTITUTED CYCLOBUTYL NUCLEOSIDE ANALOGS FOR THE TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION EMORY UNIVERSITY (US) 2007-09-05 EP disclosed
US-20060223835-A1 2' and 3'- substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation EMORY UNIVERSITY 2006-10-05 US disclosed
WO-2006063281-A2 2' AND 3' - SUBSTITUTED CYCLOBUTYL NUCLEOSIDE ANALOGS FOR THE TREATMENT OF VIRAL INFECTIONS AND ABNORMAL CELLULAR PROLIFERATION EMORY UNIVERSITY (US) 2006-06-15 WO disclosed
EP-0265506-A1 A PRODRUG FORM OF 5-FLUOROURACIL AND A METHOD OF TREATMENT OF CANCER FARMACEUTISK LABORATORIUM FERRING A/S (DK) 1988-05-04 EP disclosed
WO-1987006581-A1 A PRODRUG FORM OF 5-FLUOROURACIL AND A METHOD OF TREATMENT OF CANCER FARMACEUTISK LABORATORIUM FERRING A/S (DK) 1987-11-05 WO disclosed
EP-0062068-B1 N-PHTHALIDYL-5-FLUOROURACIL DERIVATIVES GRELAN PHARMACEUTICAL CO., LTD. (JP) 1985-06-12 EP disclosed
US-4481203-A ANTICANCER AGENTS TAIHO PHARMACEUTICAL COMPANY, LIMITED (JP) 1984-11-06 US disclosed
EP-0062068-A1 N-PHTHALIDYL-5-FLUOROURACIL DERIVATIVES GRELAN PHARMACEUTICAL CO., LTD. (JP) 1982-10-13 EP disclosed
US-4088646-A ANTITUMOR AND ANTICARCINOGENIC AGENTS ASAHI KASEI KOGYO KABUSHIKI KAISHA (JA) 1978-05-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240199604-A1 SUPRAMOLECULAR POLYMER THERAPEUTICS AND DIAGNOSTICS MAPT, HTT, PSEN1 TYMP 739/4885KMT2A 4123/4885P2RX4 3587/4885
US-20060223835-A1 2' and 3'- substituted cyclobutyl nucleoside analogs for the treatment of viral infections and abnormal cellular proliferation HAVCR2, PNP, DCTD TYMP 6/4885KMT2A 4065/4885P2RX4 2205/4885
US-20230357168-A1 CARBOBICYCLIC NUCLEOSIDES FOR TREATMENT OF VIRAL INFECTION PNP, SLC29A1, SLC29A2 TYMP 17/4885KMT2A 2720/4885P2RX4 684/4885
US-20170218001-A1 PHOSPHONATE NUCLEOSIDES USEFUL IN THE TREATMENT OF VIRAL DISEASES NR3C1, NR2E3, NR2E1 TYMP 362/4885KMT2A 1571/4885P2RX4 456/4885
US-20240197682-A1 METHOD FOR TREATING NEUROLOGICAL DISEASES USING SUPRAMOLECULE POLYMER THERAPEUTICS PRNP, PSEN1, SNCA TYMP 2654/4885KMT2A 4760/4885P2RX4 4044/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.