Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.53 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 13/20 | 0.68 |
| ▸ | RAB9A | P51151 | 13/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.68 |
| ▸ | MEN1 | O00255 | 3/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.66 |
| ▸ | TSHR | P16473 | 5/20 | 0.66 |
| ▸ | MAPT | P10636 | 5/20 | 0.66 |
| ▸ | TP53 | P04637 | 5/20 | 0.66 |
| ▸ | HPGD | P15428 | 4/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL5999620 | 1.00 | DGAT1 (0.69) | DGAT1NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL9610048 | 0.97 | DGAT1 (0.72) | DGAT1NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL2245998 | 0.97 | DGAT1 (0.72) | DGAT1NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL861223 | 0.89 | NPC1 (0.74) | DGAT1NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL2801025 | 0.85 | NPC1 (0.86) | DGAT1NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL2159951 | 0.84 | NPC1 (0.74) | DGAT1NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL14579893 | 0.83 | DGAT1 (0.56) | DGAT1NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL28628120 | 0.82 | DGAT1 (0.60) | DGAT1NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL15718167 | 0.82 | DGAT1 (1.00) | DGAT1NPC1RAB9AALDH1A1MEN1 | |
| SCHEMBL930622 | 0.82 | NPC1 (0.61) | DGAT1NPC1RAB9AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060073357-A1 | Carbazole compounds and use of such compounds in organic electroluminiscent devices | KONINKLIJKE PHILIPS ELECTRONICS, N.V. (NL) | 2006-04-06 | — | — | US | disclosed |
| EP-1594939-A2 | CARBAZOLE COMPOUNDS AND USE OF SUCH COMPOUNDS IN ORGANIC ELECTROLUMINESCENT DEVICES | Koninklijke Philips Electronics N.V. (NL) | 2005-11-16 | — | — | EP | disclosed |
| WO-2004072205-A2 | CARBAZOLE COMPOUNDS AND USE OF SUCH COMPOUNDS IN ORGANIC ELECTROLUMINESCENT DEVICES | KONINKLIJKE PHILIPS ELECTRONICS N.V. (NL) | 2004-08-26 | — | — | WO | disclosed |