Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC34A2 | O95436 | 1/20 | 0.34 |
| ▸ | SMYD2 | Q9NRG4 | 3/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.32 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | RAF1 | P04049 | 2/20 | 0.31 |
| ▸ | BRAF | P15056 | 2/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.30 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.30 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL39823 | 0.84 | SLC34A2 (0.46) | SLC34A2CHRM3LCKKDRMAPK14 | |
| SCHEMBL40118 | 0.83 | CHRM3 (0.43) | SLC34A2SMYD2CHRM3KDM1AHDAC1 | |
| SCHEMBL40112 | 0.80 | SLC34A2 (0.48) | SLC34A2SMYD2LCKKDRMAPK14 | |
| SCHEMBL2732066 | 0.78 | CHRM3 (0.44) | SLC34A2CHRM3KDM1AHDAC1RAF1 | |
| SCHEMBL40137 | 0.78 | CHRM3 (0.43) | SLC34A2SMYD2CHRM3RAF1BRAF | |
| SCHEMBL46678 | 0.76 | SLC34A2 (0.48) | SLC34A2CHRM3RAF1BRAF | |
| SCHEMBL15432568 | 0.76 | SLC34A2 (0.45) | SLC34A2SMYD2LCKKDRMAPK14 | |
| SCHEMBL46984 | 0.76 | KDM1A (0.42) | SLC34A2SMYD2KDM1AHDAC1 | |
| SCHEMBL39969 | 0.75 | SLC34A2 (0.45) | SLC34A2SMYD2KDM1AHDAC1RAF1 | |
| SCHEMBL46529 | 0.74 | SLC34A2 (0.46) | SLC34A2SMYD2KDM1AHDAC1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |