Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 3/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.36 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 12/20 | 0.32 |
| ▸ | HTR2A | P28223 | 7/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5999774 | 0.93 | SLC6A4 (0.34) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL6000197 | 0.87 | SLC6A4 (0.33) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL5999787 | 0.83 | SLC6A4 (0.33) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL6000011 | 0.79 | RHEB (0.44) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL5998864 | 0.78 | SLC6A4 (0.54) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL6000033 | 0.78 | SLC6A4 (0.48) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL6000206 | 0.74 | ADRB2 (0.35) | HTR2AADRB2 | |
| SCHEMBL6000549 | 0.74 | HTR2A (0.41) | SLC6A4HTR2AKCNH2SLC6A2 | |
| SCHEMBL5999748 | 0.73 | RHEB (0.41) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 | |
| SCHEMBL5497114 | 0.73 | SLC6A4 (0.46) | SLC6A4HTR2AKCNH2SLC6A2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060058361-A1 | Therapeutic diphenyl ether ligands | PFIZER INC | 2006-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058361-A1 | Therapeutic diphenyl ether ligands | HTR2B, HTR2C, HTR3B | PDE4D 1195/4885PDE4A 854/4885PDE4B 707/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.