Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 11/20 | 0.66 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 4/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.41 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | MPO | P05164 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6000281 | 0.82 | RHEB (0.66) | RHEBHTR2ASLC6A4KCNH2 | |
| SCHEMBL6000215 | 0.80 | RHEB (0.46) | RHEBHTR2ATRPM8CHEK1SLC6A4 | |
| SCHEMBL20536492 | 0.80 | RHEB (1.00) | RHEBTRPA1SCN9A | |
| SCHEMBL20535781 | 0.77 | RHEB (1.00) | RHEBTRPA1SCN9ASLC6A4 | |
| SCHEMBL5999729 | 0.75 | AHR (0.49) | RHEBHTR2ATRPM8CHEK1SLC6A4 | |
| SCHEMBL1499400 | 0.74 | RHEB (0.73) | RHEBTRPA1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5497887 | 0.74 | RHEB (0.51) | RHEBHTR2ATRPM8HTR1DHTR6 | |
| SCHEMBL16632580 | 0.73 | RHEB (0.63) | RHEBTRPA1HTR2CHTR6SLC6A4 | |
| SCHEMBL5501246 | 0.73 | TAAR1 (0.50) | HTR2ATAAR1SLC6A4KCNH2 | |
| SCHEMBL20535840 | 0.73 | RHEB (1.00) | RHEBTRPA1HTR2ASLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060058361-A1 | Therapeutic diphenyl ether ligands | PFIZER INC | 2006-03-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058361-A1 | Therapeutic diphenyl ether ligands | HTR2B, HTR2C, HTR3B | RHEB 2914/4885TRPA1 172/4885HTR2A 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.