Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RHEB | Q15382 | 6/20 | 0.73 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.69 |
| ▸ | AHR | P35869 | 1/20 | 0.54 |
| ▸ | HTR1B | P28222 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 6/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23709718 | 0.87 | RHEB (0.79) | RHEBTRPA1AHRHTR1BMEN1 | |
| SCHEMBL20536057 | 0.87 | TRPA1 (0.74) | RHEBTRPA1AHRHTR1BMEN1 | |
| SCHEMBL4716647 | 0.86 | RHEB (0.69) | RHEBTRPA1AHRHTR1BMEN1 | |
| SCHEMBL20536085 | 0.86 | RHEB (1.00) | RHEBTRPA1AHRHTR1BMEN1 | |
| SCHEMBL30681623 | 0.84 | AHR (0.57) | RHEBTRPA1AHRHTR1BMEN1 | |
| SCHEMBL9687165 | 0.83 | RHEB (0.55) | RHEBTRPA1AHRHTR1BMEN1 | |
| SCHEMBL23709518 | 0.83 | RHEB (0.73) | RHEBTRPA1AHRHTR1BMEN1 | |
| SCHEMBL12320529 | 0.83 | RHEB (0.59) | RHEBTRPA1AHRHTR1BMEN1 | |
| SCHEMBL321761 | 0.83 | RHEB (0.54) | RHEBTRPA1AHRHTR1BMEN1 | |
| SCHEMBL7809978 | 0.83 | RHEB (0.54) | RHEBTRPA1AHRHTR1BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2011508053-A | — | — | 2011-03-10 | — | — | JP | claimed |
| EP-2242776-A1 | MOLAR RATIO MODIFICATIONS TO LARGER POLYOLEFIN CATALYSTS | BASF Corporation (US) | 2010-10-27 | — | — | EP | claimed |
| WO-2009088596-A1 | MOLAR RATIO MODIFICATIONS TO LARGER POLYOLEFIN CATALYSTS | BASF CATALYSTS LLC (US) | 2009-07-16 | — | — | WO | claimed |
| US-6242450-B1 | SUBSTITUTED PIPERIDINES | ELI LILLY AND COMPANY | 2001-06-05 | — | — | US | disclosed |
| WO-2000006082-A2 | TREATMENT OF ANXIETY DISORDERS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| WO-2000006166-A1 | 5-HT1F ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |
| EP-0976746-A1 | 5-HT1F antagonists | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0976747-A2 | Use of 5HT-1F receptor antagonists for treating anxiety disorders | ELI LILLY AND COMPANY (US) | 2000-02-02 | — | — | EP | disclosed |