Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 2/20 | 0.36 |
| ▸ | RAF1 | P04049 | 2/20 | 0.36 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16355203 | 0.89 | NTRK1 (0.35) | NTRK1RAF1BRAFEGFRAURKA | |
| SCHEMBL46686 | 0.84 | SMN1; SMN2 (0.40) | NTRK1RAF1BRAFMEN1KMT2A | |
| SCHEMBL47765 | 0.82 | SLC34A2 (0.46) | RAF1BRAFMAPK14HDAC1KDM1A | |
| SCHEMBL6002496 | 0.80 | BRAF (0.47) | RAF1BRAFMAPK14TRPV4 | |
| SCHEMBL46779 | 0.80 | TAOK3 (0.44) | MEN1KMT2AAURKA | |
| SCHEMBL5998771 | 0.80 | BRAF (0.46) | RAF1BRAFMAPK14TRPV4 | |
| SCHEMBL6000389 | 0.79 | BRAF (0.46) | RAF1BRAFMAPK14TRPV4 | |
| SCHEMBL5998372 | 0.78 | BRAF (0.46) | RAF1BRAFMAPK14HDAC1KDM1A | |
| SCHEMBL5998740 | 0.77 | SLC34A2 (0.46) | RAF1BRAFMAPK14HDAC1KDM1A | |
| SCHEMBL46989 | 0.77 | SLC34A2 (0.46) | RAF1BRAFMAPK14HDAC1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012054110-A2 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-04-26 | — | — | WO | disclosed |
| WO-2012006475-A1 | COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT | ARDELYX, INC. (US) | 2012-01-12 | — | — | WO | disclosed |