Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.31 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.31 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.31 |
| ▸ | MGLL | Q99685 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL581760 | 0.96 | KDM4E (0.37) | KDM4ETSHRSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL3063338 | 0.96 | KDM4E (0.37) | KDM4ETSHRSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL581133 | 0.96 | KDM4E (0.37) | KDM4ETSHRSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL3078762 | 0.88 | ALDH1A1 (0.35) | KDM4ETSHRSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL3074921 | 0.88 | ALDH1A1 (0.35) | KDM4ETSHRSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL581047 | 0.88 | ALDH1A1 (0.35) | KDM4ETSHRSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL580874 | 0.88 | CHRNB4 (0.35) | CD274CHRNB4CHRNA3 | |
| SCHEMBL581402 | 0.86 | SMN1; SMN2 (0.38) | KDM4ETSHRSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL3069685 | 0.86 | SMN1; SMN2 (0.38) | KDM4ETSHRSMN1; SMN2POLBALDH1A1 | |
| SCHEMBL581403 | 0.86 | SMN1; SMN2 (0.38) | KDM4ETSHRSMN1; SMN2POLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417131-A1 | ISOXAZOL-3(2H)-ONE ANALOGS AS THERAPEUTIC AGENTS | AstraZeneca AB (SE) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010117323-A1 | METHOD AND APPARATUS FOR PRODUCING HEAT ENERGY AND CARBON DIOXIDE | ASTRAZENECA AB (SE) | 2010-10-14 | — | — | WO | disclosed |