Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 1.00 |
| ▸ | ALDH3A1 | P30838 | 2/20 | 0.69 |
| ▸ | EPAS1 | Q99814 | 6/20 | 0.67 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.43 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6000293 | 1.00 | PTPN1 (1.00) | PTPN1ALDH3A1EPAS1HSPB1ALDH1A1 | |
| SCHEMBL6001963 | 0.88 | PTPN1 (0.77) | PTPN1ALDH3A1EPAS1HSPB1ALDH1A1 | |
| SCHEMBL7170111 | 0.84 | PTPN1 (0.72) | PTPN1ALDH3A1EPAS1HSPB1ALDH1A1 | |
| SCHEMBL6000377 | 0.84 | PTPN1 (0.70) | PTPN1ALDH3A1EPAS1ALDH1A1MAPT | |
| SCHEMBL6000240 | 0.81 | PTPN1 (0.67) | PTPN1ALDH3A1EPAS1ALDH1A1MAPT | |
| SCHEMBL6001782 | 0.80 | PTPN1 (0.67) | PTPN1ALDH3A1EPAS1ALDH1A1MAPT | |
| SCHEMBL29257164 | 0.80 | PTPN1 (0.67) | PTPN1ALDH3A1EPAS1ALDH1A1MAPT | |
| SCHEMBL6000219 | 0.78 | ALDH3A1 (0.66) | PTPN1ALDH3A1EPAS1ALDH1A1MAPT | |
| SCHEMBL6001799 | 0.76 | ALDH3A1 (0.62) | PTPN1ALDH3A1EPAS1ALDH1A1MAPT | |
| SCHEMBL6001772 | 0.74 | PTPN1 (0.58) | PTPN1ALDH3A1EPAS1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1212296-B9 | PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS | SUGEN INC (US) | 2006-05-10 | — | — | EP | claimed |
| EP-1212296-B1 | PHOSPHATE MIMICS AND METHODS OF TREATMENT USING PHOSPHATASE INHIBITORS | SUGEN INC (US) | 2005-11-09 | — | — | EP | claimed |