Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 5/20 | 0.45 |
| ▸ | MET | P08581 | 11/20 | 0.45 |
| ▸ | RET | P07949 | 3/20 | 0.40 |
| ▸ | KDR | P35968 | 7/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 6/20 | 0.38 |
| ▸ | TEK | Q02763 | 6/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 6/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 4/20 | 0.38 |
| ▸ | LYN | P07948 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 2/20 | 0.37 |
| ▸ | FGR | P09769 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3931480 | 0.81 | AXL (0.48) | AXLMETRETKDRPDGFRA | |
| SCHEMBL1895977 | 0.80 | AXL (0.45) | AXLMETKDRPDGFRAKIT | |
| SCHEMBL1893324 | 0.79 | KDR (0.51) | AXLMETRETKDRPDGFRA | |
| SCHEMBL1249397 | 0.79 | FGFR4 (0.57) | AXLMETRETKDRPDGFRA | |
| SCHEMBL5363802 | 0.78 | MET (0.40) | AXLMETRETKDRPDGFRA | |
| SCHEMBL1892485 | 0.78 | KDR (0.53) | AXLMETRETKDRPDGFRA | |
| SCHEMBL12503581 | 0.78 | AXL (0.46) | AXLMETKDRPDGFRAKIT | |
| SCHEMBL1894631 | 0.76 | AXL (0.44) | AXLMETRETKDRPDGFRA | |
| SCHEMBL1892065 | 0.76 | KDR (0.69) | AXLMETKDRPDGFRAKIT | |
| SCHEMBL1897216 | 0.76 | KDR (0.59) | AXLMETRETKDRPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060135486-A1 | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors | EISAI CO., LTD. (JP) | 2006-06-22 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060135486-A1 | Use of sulfonamide-including compounds in combination with angiogenesis inhibitors | FLT4, KDR, FLT1 | AXL 198/4885MET 862/4885RET 1075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.