Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 4/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.33 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.33 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.33 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | DHFR | P00374 | 1/20 | 0.31 |
| ▸ | IAPP | P10997 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28284921 | 0.84 | GABRA1 (0.36) | GABRA1GABRB2TAAR1HTR1APTGER1 | |
| SCHEMBL11215662 | 0.81 | GABRA1 (0.40) | GABRA1GABRB2TAAR1HTR1AKCNH2 | |
| SCHEMBL5528070 | 0.81 | GABRA1 (0.40) | GABRA1GABRB2TAAR1HTR1APTGER1 | |
| SCHEMBL10744107 | 0.78 | GABRA1 (0.36) | GABRA1GABRB2PTGER1PTGER4PTGER3 | |
| SCHEMBL3079662 | 0.77 | GABRA1 (0.32) | GABRA1GABRB2TAAR1PTGER1PTGER4 | |
| SCHEMBL6546138 | 0.76 | CHAT (0.51) | PTGER4PTGER3PTGER2 | |
| SCHEMBL3314632 | 0.76 | CHAT (0.51) | PTGER4PTGER3PTGER2 | |
| SCHEMBL547944 | 0.76 | MEN1 (0.44) | GABRA1GABRB2TAAR1HTR1AKCNH2 | |
| SCHEMBL4903482 | 0.75 | GABRA1 (0.41) | GABRA1GABRB2TAAR1HTR1AKCNH2 | |
| SCHEMBL16958549 | 0.75 | GABRA1 (0.46) | GABRA1GABRB2TAAR1HTR1AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |