Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27521423 | 0.98 | TSHR (0.49) | TSHRCYP3A4TP53MAPK1LMNA | |
| SCHEMBL8915435 | 0.98 | TSHR (0.49) | TSHRCYP3A4TP53MAPK1LMNA | |
| SCHEMBL20526214 | 0.98 | TSHR (0.49) | TSHRCYP3A4TP53MAPK1LMNA | |
| SCHEMBL29575676 | 0.96 | TSHR (0.47) | TSHRCYP3A4TP53MAPK1LMNA | |
| SCHEMBL30528958 | 0.96 | TSHR (0.47) | TSHRCYP3A4TP53MAPK1LMNA | |
| SCHEMBL6002555 | 0.94 | TSHR (0.46) | TSHRCYP3A4TP53MAPK1LMNA | |
| SCHEMBL11286528 | 0.86 | LMNA (0.46) | TSHRCYP3A4TP53MAPK1LMNA | |
| SCHEMBL28316278 | 0.85 | LMNA (0.44) | TSHRCYP3A4TP53MAPK1LMNA | |
| SCHEMBL6745076 | 0.84 | RECQL (0.46) | TSHRCYP3A4TP53MAPK1LMNA | |
| Tetrabuthylammonium SCHEMBL5702394 | 0.79 | SLC22A1 (0.41) | TSHRCYP3A4TP53MAPK1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |