Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.43 |
| ▸ | HAO1 | Q9UJM8 | 2/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.37 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2161069 | 0.79 | HAO1 (0.44) | HRH3HAO1KCNH2MAPTALDH1A1 | |
| SCHEMBL2586793 | 0.79 | HRH3 (0.44) | HRH3HAO1KCNH2MAPTALDH1A1 | |
| SCHEMBL4540000 | 0.79 | HRH3 (0.44) | HRH3HAO1KCNH2MAPTALDH1A1 | |
| SCHEMBL5292221 | 0.79 | ALDH1A1 (0.40) | MAPTALDH1A1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL6704196 | 0.76 | HAO1 (0.59) | HRH3HAO1KCNH2MAPTALDH1A1 | |
| SCHEMBL42782 | 0.74 | HDAC8 (0.52) | HRH3HAO1KCNH2MAPTSMN1; SMN2 | |
| SCHEMBL6275125 | 0.74 | HDAC8 (0.52) | HRH3HAO1KCNH2MAPTSMN1; SMN2 | |
| SCHEMBL28584923 | 0.74 | HDAC8 (0.52) | HRH3HAO1KCNH2MAPTSMN1; SMN2 | |
| SCHEMBL15260520 | 0.74 | HDAC8 (0.52) | HRH3HAO1KCNH2MAPTSMN1; SMN2 | |
| SCHEMBL1992931 | 0.72 | ALDH1A1 (0.59) | HRH3HAO1KCNH2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |