Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 8/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.46 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | KIF5B | P33176 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.45 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.42 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.42 |
| ▸ | CSF1R | P07333 | 2/20 | 0.41 |
| ▸ | FLT4 | P35916 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3897825 | 0.86 | SRC (0.50) | PDPK1PDGFRBPDGFRAEGFRPDE10A | |
| SCHEMBL6004216 | 0.82 | LCK (0.50) | PDGFRBPDGFRAKDREGFRLCK | |
| SCHEMBL6004691 | 0.81 | TGFBR1 (0.52) | ATMKDREGFRLCKRET | |
| SCHEMBL3901753 | 0.80 | PDPK1 (0.55) | PDPK1KDRMET | |
| SCHEMBL3903438 | 0.80 | SRC (0.46) | PDPK1PDGFRBPDGFRAKDRPDE10A | |
| SCHEMBL4725061 | 0.79 | ATM (0.57) | ATMPDPK1PDGFRBPDGFRAKDR | |
| SCHEMBL3907471 | 0.79 | SRC (0.44) | PDPK1PDGFRBPDGFRAKDRPDE10A | |
| SCHEMBL6004743 | 0.79 | KDR (0.50) | PDGFRBKDREGFRLCKRET | |
| SCHEMBL3895797 | 0.79 | KDR (0.47) | PDGFRBPDGFRAKDREGFRLCK | |
| SCHEMBL3897241 | 0.78 | SRC (0.45) | PDPK1PDGFRBPDGFRAKDRPDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |