Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 4/20 | 0.68 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL447419 | 0.88 | IDO1 (0.66) | IDO1GPR84 | |
| SCHEMBL15330041 | 0.84 | IDO1 (0.72) | IDO1GPR84SLC6A4GID4ADRA2A | |
| SCHEMBL180403 | 0.84 | IDO1 (0.72) | IDO1GPR84SLC6A4GID4ADRA2A | |
| SCHEMBL4209937 | 0.81 | IDO1 (0.64) | IDO1GPR84SLC6A4GID4ADRA2A | |
| SCHEMBL17115833 | 0.81 | IDO1 (0.68) | IDO1GPR84SLC6A4GID4ADRA2A | |
| SCHEMBL7710711 | 0.81 | IDO1 (0.68) | IDO1GPR84SLC6A4GID4ADRA2A | |
| SCHEMBL2472307 | 0.81 | IDO1 (0.68) | IDO1GPR84SLC6A4GID4HTT | |
| SCHEMBL12727345 | 0.81 | IDO1 (0.68) | IDO1GPR84SLC6A4GID4HTT | |
| SCHEMBL31235704 | 0.81 | IDO1 (0.68) | IDO1GPR84SLC6A4GID4HTT | |
| SCHEMBL31251494 | 0.81 | IDO1 (0.68) | IDO1GPR84SLC6A4GID4HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |