Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.42 |
| ▸ | DRD1 | P21728 | 2/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5859620 | 0.83 | IDO1 (0.36) | DRD3SLC6A2CYP2D6CHRM2ADRA2A | |
| SCHEMBL9021303 | 0.77 | IDO1 (0.36) | CYP2D6HRH1SIGMAR1IDO1MEN1 | |
| SCHEMBL1828238 | 0.73 | HRH1 (0.40) | SLC6A2SLC6A3SLC6A4HRH1LMNA | |
| SCHEMBL10727267 | 0.72 | DRD3 (0.62) | DRD3SLC6A2CYP2D6CHRM2ADRA2A | |
| SCHEMBL11070013 | 0.71 | HRH1 (0.39) | SLC6A2SLC6A3SLC6A4HRH1IDO1 | |
| SCHEMBL9439904 | 0.70 | HTT (0.44) | SLC6A3HTT | |
| SCHEMBL8643817 | 0.69 | DRD3 (0.59) | DRD3SLC6A2CYP2D6CHRM2ADRA2A | |
| SCHEMBL447548 | 0.69 | PSEN1 (0.39) | OPRM1HRH3MAPK1SIGMAR1MEN1 | |
| SCHEMBL2202292 | 0.68 | GAA (0.37) | CYP2D6SIGMAR1IDO1MAPTMEN1 | |
| SCHEMBL2094948 | 0.68 | SLC6A3 (0.41) | DRD3SLC6A2CYP2D6CHRM2ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005042542-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO (2,1-B) OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2005-05-12 | — | — | WO | disclosed |