Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4889034 | 0.90 | TACR1 (0.35) | NR1H2NR1H3TACR1 | |
| SCHEMBL6003957 | 0.90 | NR1H2 (0.46) | NR1H2NR1H3TACR1 | |
| SCHEMBL6002684 | 0.87 | TACR1 (0.36) | NR1H2NR1H3TACR1 | |
| SCHEMBL4899277 | 0.85 | CD38 (0.35) | NR1H2NR1H3TACR1 | |
| SCHEMBL6004214 | 0.84 | TACR1 (0.33) | NR1H2NR1H3TACR1 | |
| SCHEMBL6005072 | 0.78 | NR1H2 (0.37) | NR1H2NR1H3TACR1 | |
| SCHEMBL6003649 | 0.68 | ENPP2 (0.38) | NR1H2NR1H3TACR1 | |
| SCHEMBL6004899 | 0.67 | NR1H2 (0.36) | NR1H2NR1H3TACR1 | |
| SCHEMBL6005068 | 0.67 | ENPP2 (0.38) | TACR1 | |
| SCHEMBL6004610 | 0.65 | TACR1 (0.36) | NR1H2NR1H3TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252807-A1 | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders | KALYPSYS, INC. | 2006-11-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252807-A1 | Novel ortho-terphenyl inhibitors of p38 kinase and methods of treating inflammatory disorders | MAPK1, MAP3K1, MAPK4 | NR1H2 744/4885NR1H3 723/4885TACR1 3601/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.