Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 11/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.34 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6005052 | 0.93 | TGFBR1 (0.44) | TGFBR1NPC1KDM4EPDGFRBPDGFRA | |
| SCHEMBL6005267 | 0.88 | TGFBR1 (0.46) | TGFBR1NPC1KDM4EALDH1A1MAPT | |
| SCHEMBL6002943 | 0.88 | TGFBR1 (0.47) | TGFBR1NPC1KDM4EMAPKAPK2 | |
| SCHEMBL6005291 | 0.88 | TGFBR1 (0.48) | TGFBR1NPC1KDM4EALDH1A1MAPT | |
| SCHEMBL6003004 | 0.87 | TGFBR1 (0.46) | TGFBR1NPC1KDM4EMAPKAPK2ALDH1A1 | |
| SCHEMBL6004154 | 0.86 | TGFBR1 (0.47) | TGFBR1NPC1KDM4E | |
| SCHEMBL6005329 | 0.85 | TGFBR1 (0.45) | TGFBR1NPC1KDM4EMAPKAPK2RAB9A | |
| SCHEMBL6004076 | 0.84 | TGFBR1 (0.46) | TGFBR1NPC1KDM4E | |
| SCHEMBL6002921 | 0.84 | TGFBR1 (0.44) | TGFBR1NPC1KDM4EALDH1A1MAPT | |
| SCHEMBL6004938 | 0.84 | TGFBR1 (0.44) | TGFBR1NPC1KDM4EMAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |