Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 5/20 | 0.52 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.46 |
| ▸ | MAPKAPK2 | P49137 | 5/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL998493 | 0.91 | MAPT (0.73) | MAPTNPSR1POLBTP53SIRT1 | |
| SCHEMBL998530 | 0.91 | MAPT (0.61) | MAPTNPSR1POLBTP53ABCG2 | |
| SCHEMBL1000924 | 0.88 | MAPT (0.62) | MAPTNPSR1POLBTP53ABCG2 | |
| SCHEMBL999699 | 0.86 | MAPT (0.59) | MAPTNPSR1POLBTP53ABCG2 | |
| SCHEMBL998795 | 0.83 | MAPT (0.56) | MAPTNPSR1POLBTP53SIRT1 | |
| SCHEMBL997405 | 0.83 | MAPT (0.62) | MAPTNPSR1POLBTP53ABCG2 | |
| SCHEMBL998332 | 0.83 | MAPT (0.74) | MAPTNPSR1POLBTP53ABCG2 | |
| SCHEMBL998642 | 0.82 | SIRT1 (0.56) | MAPTPOLBTP53ABCG2SIRT1 | |
| SCHEMBL999602 | 0.81 | MAPT (0.67) | MAPTNPSR1POLBTP53ABCG2 | |
| SCHEMBL998555 | 0.81 | MAPT (0.63) | MAPTNPSR1POLBTP53ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1637521-B1 | NOVEL TRICYCLIC HETEROCYCLE COMPOUND | ONO PHARMACEUTICAL CO (JP) | 2013-06-19 | — | — | EP | disclosed |
| EP-1637521-A1 | NOVEL TRICYCLIC HETEROCYCLE COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-03-22 | — | — | EP | disclosed |