Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | COMT | P21964 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 1/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6004731 | 0.84 | IDO1 (0.37) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL3947063 | 0.80 | KDM4E (0.44) | KDM4EGAAKMT2AL3MBTL1METAP1 | |
| SCHEMBL29769309 | 0.77 | KDM4E (0.55) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL687180 | 0.77 | KDM4E (0.55) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL6002898 | 0.76 | CYP2A6 (0.42) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL22165268 | 0.75 | ALDH1A1 (0.55) | KDM4EALDH1A1HPGDHSD17B10MAPT | |
| SCHEMBL3893914 | 0.72 | KDM4E (0.42) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL3943759 | 0.70 | CCR1 (0.47) | KDM4EALDH1A1HSD17B10KMT2AMETAP2 | |
| SCHEMBL28897793 | 0.70 | ALDH1A1 (0.50) | KDM4EALDH1A1HPGDGAAHSD17B10 | |
| SCHEMBL3891690 | 0.69 | KDM4E (0.47) | KDM4EALDH1A1HPGDGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |