Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 4/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.47 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3894958 | 0.91 | SRC (0.49) | KDRPDGFRAFGFR2PDGFRB | |
| SCHEMBL3895779 | 0.90 | FGFR2 (0.53) | KDRPDGFRAFGFR2PDGFRBEGFR | |
| SCHEMBL6004223 | 0.90 | PDGFRA (0.48) | KDRPDGFRAFGFR2METPDGFRB | |
| SCHEMBL6004575 | 0.89 | PDGFRB (0.48) | KDRPDGFRAFGFR2PDGFRBEGFR | |
| SCHEMBL6003892 | 0.87 | PRKDC (0.45) | PDGFRAFGFR2PDGFRBEGFR | |
| SCHEMBL6004321 | 0.87 | FGFR2 (0.44) | KDRPDGFRAFGFR2PDGFRBAXL | |
| SCHEMBL6004787 | 0.85 | PDGFRB (0.49) | KDRPDGFRAFGFR2PDGFRBEGFR | |
| SCHEMBL6004734 | 0.84 | EGFR (0.51) | PDGFRAFGFR2PDGFRBEGFR | |
| SCHEMBL6005269 | 0.84 | FGFR2 (0.47) | KDRPDGFRAFGFR2PDGFRBAXL | |
| SCHEMBL6004765 | 0.83 | FGFR2 (0.45) | KDRPDGFRAFGFR2PDGFRBAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |