Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.32 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.32 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.31 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.30 |
| ▸ | CASP6 | P55212 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29622975 | 0.77 | AAK1 (0.40) | KMOEPHB4LRRK2 | |
| SCHEMBL4758327 | 0.77 | AAK1 (0.40) | KMOEPHB4LRRK2 | |
| SCHEMBL6473651 | 0.74 | CYP1A2 (0.34) | KMOEPHB4 | |
| SCHEMBL4655567 | 0.72 | AXL (0.42) | KMOALOX15HSD17B10NR4A2SOS2 | |
| SCHEMBL15056561 | 0.72 | CYP17A1 (0.38) | LRRK2ALDH1A1ALOX15HSD17B10NR4A2 | |
| SCHEMBL15578362 | 0.72 | LRRK2 (0.30) | LRRK2ALDH1A1ALOX15HSD17B10NR4A2 | |
| SCHEMBL9984695 | 0.71 | PARP1 (0.44) | PDE4BPDE4DALDH1A1ALOX15HSD17B10 | |
| SCHEMBL6033046 | 0.70 | AAK1 (0.32) | — | |
| SCHEMBL1556897 | 0.69 | NR4A2 (0.44) | ALDH1A1ALOX15HSD17B10NR4A2SOS2 | |
| SCHEMBL30800065 | 0.69 | NR4A2 (0.44) | ALDH1A1ALOX15HSD17B10NR4A2SOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |