Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | ATR | Q13535 | 1/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | PRNP | P04156 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30426588 | 0.88 | CA12 (0.44) | KDM4EATRPSMD14LMNAKMT2A | |
| SCHEMBL22505611 | 0.88 | CA12 (0.44) | KDM4EATRPSMD14LMNAKMT2A | |
| SCHEMBL22766449 | 0.87 | KDM4E (0.42) | KDM4EATRPSMD14LMNAKMT2A | |
| SCHEMBL1132184 | 0.87 | GAA (0.51) | KDM4ELMNAKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL21200688 | 0.87 | KDM4E (0.42) | KDM4EATRPSMD14LMNAKMT2A | |
| Hydrochloric Acid SCHEMBL1892857 | 0.86 | GAA (0.50) | KDM4ELMNAKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL21200883 | 0.85 | MET (0.47) | KDM4EATRPSMD14LMNAKMT2A | |
| SCHEMBL6004313 | 0.84 | GAA (0.51) | KDM4ELMNAKMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL22505740 | 0.82 | GAA (0.46) | KDM4ELMNAKMT2AMEN1MAPT | |
| SCHEMBL1895818 | 0.82 | FLT1 (0.46) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |