Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 3/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.42 |
| ▸ | KDR | P35968 | 3/20 | 0.41 |
| ▸ | IGF1R | P08069 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | AXL | P30530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3895779 | 0.92 | FGFR2 (0.53) | FGFR2EGFRPDGFRBPDGFRASRC | |
| SCHEMBL6005276 | 0.88 | SRC (0.44) | FGFR2PDGFRBPDGFRASRCTGFBR1 | |
| SCHEMBL6004093 | 0.88 | MET (0.45) | FGFR2PDGFRBPDGFRASRCTGFBR1 | |
| SCHEMBL6004765 | 0.87 | FGFR2 (0.45) | FGFR2PDGFRBPDGFRASRCTGFBR1 | |
| SCHEMBL6004321 | 0.86 | FGFR2 (0.44) | FGFR2PDGFRBPDGFRASRCTGFBR1 | |
| SCHEMBL6004849 | 0.86 | MET (0.45) | FGFR2SRCTGFBR1KDRMET | |
| SCHEMBL6002948 | 0.86 | FGFR2 (0.47) | FGFR2PDGFRBPDGFRASRCTGFBR1 | |
| SCHEMBL6005269 | 0.85 | FGFR2 (0.47) | FGFR2PDGFRBPDGFRASRCTGFBR1 | |
| SCHEMBL6004869 | 0.84 | SRC (0.46) | FGFR2PDGFRBPDGFRASRCTGFBR1 | |
| SCHEMBL6002798 | 0.84 | SRC (0.46) | FGFR2PDGFRBPDGFRASRCTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |