Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 11/20 | 0.53 |
| ▸ | CSF1R | P07333 | 5/20 | 0.50 |
| ▸ | KDR | P35968 | 3/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.50 |
| ▸ | AURKA | O14965 | 2/20 | 0.50 |
| ▸ | MET | P08581 | 2/20 | 0.50 |
| ▸ | TEK | Q02763 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 2/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.48 |
| ▸ | ERN1 | O75460 | 1/20 | 0.48 |
| ▸ | STK10 | O94804 | 1/20 | 0.48 |
| ▸ | MAP3K6 | O95382 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | RET | P07949 | 1/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.48 |
| ▸ | KIT | P10721 | 1/20 | 0.48 |
| ▸ | BCR | P11274 | 1/20 | 0.48 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1323767 | 0.94 | KDR (0.56) | IRAK4CSF1RKDRAURKBAURKA | |
| SCHEMBL31218187 | 0.94 | KDR (0.56) | IRAK4CSF1RKDRAURKBAURKA | |
| SCHEMBL6004313 | 0.86 | GAA (0.51) | KDRKDM4EFGFR1PDGFRA | |
| SCHEMBL17137547 | 0.85 | IRAK4 (0.65) | IRAK4 | |
| SCHEMBL2174075 | 0.84 | KDR (0.50) | KDRAURKBAURKAMETTEK | |
| Methylamine SCHEMBL22505658 | 0.82 | AXL (0.49) | KDRAURKBAURKAMETTEK | |
| SCHEMBL1891155 | 0.82 | SRC (0.44) | KDRAURKBAURKAMETTEK | |
| SCHEMBL1132245 | 0.82 | AXL (0.51) | METKDM4E | |
| SCHEMBL27104752 | 0.81 | IRAK4 (0.51) | IRAK4CSF1RKDRAURKBAURKA | |
| SCHEMBL22505587 | 0.81 | AXL (0.53) | IRAK4CSF1RKDRAURKBAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1724268-A1 | COMPOUND HAVING TGF-BETA INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION CONTAINING SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 2006-11-22 | — | — | EP | disclosed |