Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCKBR | P32239 | 16/20 | 0.65 |
| ▸ | CCKAR | P32238 | 11/20 | 0.55 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6005845 | 0.86 | CCKBR (0.61) | CCKBRCCKAR | |
| SCHEMBL6003807 | 0.83 | CCKBR (0.66) | CCKBRCCKAR | |
| SCHEMBL6005180 | 0.81 | CCKBR (0.67) | CCKBRCCKAR | |
| SCHEMBL643277 | 0.80 | CCKBR (0.68) | CCKBRCCKARBDKRB1 | |
| SCHEMBL7095785 | 0.80 | CCKBR (0.58) | CCKBRCCKAR | |
| SCHEMBL644096 | 0.79 | CCKBR (1.00) | CCKBRCCKAR | |
| SCHEMBL9526461 | 0.79 | CCKBR (1.00) | CCKBRCCKAR | |
| SCHEMBL7167513 | 0.79 | CCKBR (0.40) | CCKBRCCKAR | |
| SCHEMBL16110814 | 0.78 | CCKBR (0.64) | CCKBRCCKAR | |
| SCHEMBL6005237 | 0.77 | CCKBR (0.57) | CCKBRCCKAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105509-B2 | Benzodiazepine derivatives as APP modulators | MERCK SHARP & DOHME LIMITED (GB) | 2006-09-12 | — | — | US | disclosed |
| US-20040082572-A1 | Benzodiazepine derivatives as app modulators | MERCK SHARPE & DOHME LIMITED (GB) | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082572-A1 | Benzodiazepine derivatives as app modulators | BACE1, PSEN1, APP | CCKBR 642/4885CCKAR 838/4885BDKRB1 364/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.