Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 13/20 | 0.69 |
| ▸ | PSEN2 | P49810 | 13/20 | 0.69 |
| ▸ | APH1B | Q8WW43 | 13/20 | 0.69 |
| ▸ | NCSTN | Q92542 | 13/20 | 0.69 |
| ▸ | APH1A | Q96BI3 | 13/20 | 0.69 |
| ▸ | PSENEN | Q9NZ42 | 13/20 | 0.69 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | CCKBR | P32239 | 3/20 | 0.47 |
| ▸ | GSAP | A4D1B5 | 1/20 | 0.47 |
| ▸ | NOTCH1 | P46531 | 1/20 | 0.46 |
| ▸ | NOTCH3 | Q9UM47 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7182508 | 0.88 | PSEN1 (0.82) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7097812 | 0.88 | CCKBR (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7196020 | 0.87 | PSEN1 (0.72) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6005228 | 0.82 | CCKBR (0.68) | SCN9ACCKBR | |
| SCHEMBL6006725 | 0.82 | CCKBR (0.68) | SCN9ACCKBR | |
| SCHEMBL6006715 | 0.82 | CCKBR (0.68) | SCN9ACCKBR | |
| SCHEMBL6005417 | 0.81 | PSEN1 (1.00) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6005982 | 0.81 | PSEN1 (0.70) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6006110 | 0.81 | SCN9A (0.48) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL6006377 | 0.80 | CCKBR (0.61) | SCN9ACCKBR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105509-B2 | Benzodiazepine derivatives as APP modulators | MERCK SHARP & DOHME LIMITED (GB) | 2006-09-12 | — | — | US | disclosed |