SCHEMBL6005459

SCHEMBL6005459

CC(OCCO)OCc1ccccc1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.45
SLC1A3 P43003 2/20 0.41
SLC1A2 P43004 2/20 0.41
SLC1A1 P43005 2/20 0.41
KMT2A Q03164 2/20 0.41
MEN1 O00255 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2D6 P10635 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
MAPT P10636 1/20 0.41
ALDH1A1 P00352 3/20 0.40
RCE1 Q9Y256 1/20 0.40
TRPA1 O75762 1/20 0.40
CA1 P00915 3/20 0.40
CA2 P00918 1/20 0.40
CA7 P43166 1/20 0.40
CA9 Q16790 1/20 0.40
KDM4E B2RXH2 1/20 0.40
POLB P06746 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1571975 0.86 TSHR (0.52) TSHRSLC1A3SLC1A2SLC1A1KMT2A
SCHEMBL9109325 0.83 TRPA1 (0.40) TSHRSLC1A3SLC1A2SLC1A1KMT2A
SCHEMBL27261214 0.81 TSHR (0.45) TSHRSLC1A3SLC1A2SLC1A1KMT2A
SCHEMBL3275844 0.81 TSHR (0.45) TSHRSLC1A3SLC1A2SLC1A1KMT2A
SCHEMBL10967301 0.81 TSHR (0.45) TSHRSLC1A3SLC1A2SLC1A1KMT2A
SCHEMBL14285713 0.81 CYP1A2 (0.52) TSHRSLC1A3SLC1A2SLC1A1KMT2A
SCHEMBL21068714 0.81 TSHR (0.45) TSHRKMT2AALDH1A1RCE1TRPA1
SCHEMBL21068518 0.81 TSHR (0.45) TSHRKMT2AALDH1A1RCE1TRPA1
SCHEMBL21068517 0.81 TSHR (0.45) TSHRKMT2AALDH1A1RCE1TRPA1
SCHEMBL27131173 0.81 CA1 (0.47) TSHRSLC1A1KMT2ACA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0859610-B1 IBOGAMINE CONGENERS ALBANY MEDICAL COLLEGE (US) 2006-01-11 EP disclosed
EP-0859610-A4 IBOGAMINE CONGENERS ALBANY MEDICAL COLLEGE (US) 2002-05-15 EP disclosed
US-6211360-B1 DRUG ABRUSE THERAPY; PLANT EXTRACTS ALBANY MEDICAL COLLEGE 2001-04-03 US disclosed
EP-0859610-A1 IBOGAMINE CONGENERS ALBANY MEDICAL COLLEGE (US) 1998-08-26 EP disclosed
WO-1997005869-A1 IBOGAMINE CONGENERS ALBANY MEDICAL COLLEGE (US) 1997-02-20 WO disclosed