Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 13/20 | 0.65 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | FNTA | P49354 | 1/20 | 0.41 |
| ▸ | FNTB | P49356 | 1/20 | 0.41 |
| ▸ | TP53BP1 | Q12888 | 1/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6008613 | 0.87 | CCR5 (0.71) | CCR5 | |
| SCHEMBL6008994 | 0.87 | CCR5 (0.69) | CCR5 | |
| SCHEMBL6009109 | 0.86 | CCR5 (0.88) | CCR5HSD11B1KMT2ACHRM2 | |
| SCHEMBL6007364 | 0.86 | CCR5 (0.61) | CCR5TP53BP1L3MBTL3L3MBTL1 | |
| SCHEMBL6007031 | 0.85 | CCR5 (0.60) | CCR5KMT2ATP53BP1L3MBTL3L3MBTL1 | |
| SCHEMBL6008620 | 0.83 | CCR5 (0.63) | CCR5 | |
| SCHEMBL6009248 | 0.82 | CCR5 (0.57) | CCR5 | |
| SCHEMBL6008414 | 0.81 | CCR5 (0.81) | CCR5CHRM2 | |
| SCHEMBL6008456 | 0.81 | CCR5 (0.81) | CCR5CHRM2 | |
| SCHEMBL6009045 | 0.81 | CCR5 (0.61) | CCR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716156-A2 | CHEMOKINE CCR5 RECEPTOR MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-11-02 | — | — | EP | claimed |
| WO-2005075484-A2 | CHEMOKINE CCR5 RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-08-18 | — | — | WO | claimed |