Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SHMT2 | P34897 | 1/20 | 0.53 |
| ▸ | ABCB1 | P08183 | 4/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL998794 | 0.83 | MAPT (0.67) | SHMT2ABCB1ABCG2TP53TRPM8 | |
| SCHEMBL1000685 | 0.74 | TP53 (0.61) | SHMT2ABCB1ABCG2TP53MAPT | |
| SCHEMBL1000817 | 0.74 | MAPT (0.71) | SHMT2ABCB1ABCG2TP53TRPM8 | |
| SCHEMBL999013 | 0.73 | TRPV1 (0.65) | TRPV1ALDH1A1 | |
| SCHEMBL1077903 | 0.73 | MAPT (0.72) | SHMT2TP53MAPTNPSR1LMNA | |
| SCHEMBL998943 | 0.72 | MAPT (0.71) | SHMT2ABCB1ABCG2TP53MAPT | |
| SCHEMBL998250 | 0.70 | MAPT (0.71) | SHMT2TP53MAPTNPSR1LMNA | |
| SCHEMBL998412 | 0.70 | MAPT (0.64) | SHMT2ABCB1ABCG2TP53MAPT | |
| SCHEMBL1078960 | 0.70 | MAPT (0.88) | SHMT2ABCB1ABCG2TP53MAPT | |
| SCHEMBL17792810 | 0.69 | SHMT2 (1.00) | SHMT2ABCB1ABCG2TP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1637521-A1 | NOVEL TRICYCLIC HETEROCYCLE COMPOUND | ONO PHARMACEUTICAL CO., LTD. (JP) | 2006-03-22 | — | — | EP | disclosed |