Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 1/20 | 0.50 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.50 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.50 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.50 |
| ▸ | SSU72 | Q9NP77 | 1/20 | 0.50 |
| ▸ | EEF2K | O00418 | 2/20 | 0.49 |
| ▸ | TACR1 | P25103 | 7/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13506600 | 0.87 | TACR1 (0.43) | ACP1PTPN7PTPN12PTPN13SSU72 | |
| SCHEMBL30434012 | 0.79 | SLC1A3 (0.59) | EEF2KNPSR1SLC1A3SLC1A2CA1 | |
| SCHEMBL2067888 | 0.77 | MMP2 (0.53) | NPSR1SLC1A3SLC1A2CA1CA2 | |
| SCHEMBL30688764 | 0.77 | EEF2K (0.57) | EEF2KSLC1A3SLC1A2MAPTCA1 | |
| SCHEMBL7589345 | 0.73 | MEN1 (0.57) | NPSR1MAPTPPARG | |
| SCHEMBL13623382 | 0.72 | CA1 (0.47) | ACP1NPSR1MAPTTDP1CA1 | |
| SCHEMBL7691895 | 0.71 | TACR1 (0.55) | ACP1PTPN7PTPN12PTPN13SSU72 | |
| SCHEMBL7093232 | 0.71 | MMP2 (0.47) | NPSR1SLC1A3SLC1A2MAPTCA1 | |
| SCHEMBL30311815 | 0.71 | CNR1 (0.41) | ACP1PTPN7PTPN12PTPN13SSU72 | |
| SCHEMBL12789659 | 0.71 | CNR1 (0.41) | ACP1PTPN7PTPN12PTPN13SSU72 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7105509-B2 | Benzodiazepine derivatives as APP modulators | MERCK SHARP & DOHME LIMITED (GB) | 2006-09-12 | — | — | US | disclosed |
| US-20040082572-A1 | Benzodiazepine derivatives as app modulators | MERCK SHARPE & DOHME LIMITED (GB) | 2004-04-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040082572-A1 | Benzodiazepine derivatives as app modulators | BACE1, PSEN1, APP | ACP1 4142/4885PTPN7 4585/4885PTPN12 4516/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.