Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 2/20 | 0.40 |
| ▸ | BCHE | P06276 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | CES1 | P23141 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10455224 | 0.77 | — | — | |
| SCHEMBL2591478 | 0.75 | — | — | |
| SCHEMBL10864094 | 0.70 | — | — | |
| SCHEMBL8686729 | 0.70 | — | — | |
| SCHEMBL9915844 | 0.67 | — | — | |
| SCHEMBL9490087 | 0.65 | CES2 (0.37) | CES2BCHEACHECES1KDM4E | |
| SCHEMBL9134442 | 0.64 | TRIM24 (0.43) | ALDH1A1TP53TSHR | |
| SCHEMBL6144841 | 0.64 | — | — | |
| SCHEMBL28464858 | 0.62 | — | — | |
| SCHEMBL18255829 | 0.61 | TRIM24 (0.50) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1017675-B1 | HIGHLY LIPOPHILIC CAMPTOTHECIN DERIVATIVES | BIONUMERIK PHARMACEUTICALS INC (US) | 2006-06-14 | — | — | EP | disclosed |
| US-6169080-B1 | TOPOISOMERASE I INHIBITORS FOR TREATING PATIENTS WITH CANCER | BIONUMERIK PHARMACEUTICALS, INC. | 2001-01-02 | — | — | US | disclosed |
| US-4309423-A | ANTIALDOSTERONES | CIBA-GEIGY CORPORATION (US) | 1982-01-05 | — | — | US | disclosed |