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Halobetasol Propionate

Halobetasol Propionate

SCHEMBL6006526

CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C.CCC(=O)O[C@]1(C(=O)CCl)[C@@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

NR3C1

The experimentally established mechanism targets of Halobetasol Propionate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ NR3C1 known ✓ P04150 10/20 0.78
▸ PGR P06401 6/20 1.00
▸ AR P10275 4/20 1.00
▸ ADORA3 P0DMS8 3/20 1.00
▸ CHRM1 P11229 1/20 1.00
▸ ADRA1A P35348 1/20 1.00
▸ CYP3A4 P08684 6/20 0.78
▸ NR1I2 O75469 3/20 0.78
▸ NR3C2 P08235 1/20 0.78
▸ SMN1; SMN2 Q16637 3/20 0.75
▸ MAPT P10636 3/20 0.75
▸ LMNA P02545 2/20 0.75
▸ USP2 O75604 2/20 0.75
▸ ABCB11 O95342 2/20 0.75
▸ MLNR O43193 1/20 0.75
▸ CYP3A5 P20815 1/20 0.75
▸ PPARG P37231 1/20 0.75
▸ NPSR1 Q6W5P4 1/20 0.75
▸ CYP2D6 P10635 1/20 0.75
▸ CYP2C9 P11712 1/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Halobetasol Propionate SCHEMBL2849994 1.00 PGR (1.00) PGRARADORA3CHRM1ADRA1A
Halobetasol Propionate SCHEMBL14518060 1.00 PGR (1.00) PGRARADORA3CHRM1ADRA1A
Halobetasol Propionate SCHEMBL6753214 1.00 PGR (1.00) PGRARADORA3CHRM1ADRA1A
Halobetasol Propionate SCHEMBL13321839 1.00 PGR (1.00) PGRARADORA3CHRM1ADRA1A
Halobetasol Propionate SCHEMBL33858 1.00 PGR (1.00) PGRARADORA3CHRM1ADRA1A
Halobetasol Propionate SCHEMBL10905947 1.00 PGR (1.00) PGRARADORA3CHRM1ADRA1A
Halobetasol Propionate SCHEMBL17190306 1.00 PGR (1.00) PGRARADORA3CHRM1ADRA1A
Halobetasol Propionate SCHEMBL10905949 1.00 PGR (1.00) PGRARADORA3CHRM1ADRA1A
Halobetasol Propionate SCHEMBL2849995 1.00 PGR (1.00) PGRARADORA3CHRM1ADRA1A
Halobetasol Propionate SCHEMBL14339615 1.00 PGR (1.00) PGRARADORA3CHRM1ADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2006110534-A2 A PROCESS FOR PREPARING A CRYSTALLINE FORM OF HALOBETASOL PROPIONATE TARO PHARMACEUTICALS U.S.A., INC. (US) 2006-10-19 — — WO disclosed
US-5326566-A As solvents, water or oil soluble surfactants BRISTOL-MYERS SQUIBB COMPANY (US) 1994-07-05 — — US disclosed
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