Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.40 |
| ▸ | ITGAV | P06756 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7057266 | 1.00 | HDAC8 (0.62) | HDAC8HDAC6HDAC2ALDH1A1TSHR | |
| SCHEMBL29164941 | 0.86 | HDAC2 (0.59) | HDAC8HDAC6HDAC2ALDH1A1TSHR | |
| SCHEMBL29164939 | 0.86 | HDAC2 (0.59) | HDAC8HDAC6HDAC2ALDH1A1TSHR | |
| SCHEMBL21563554 | 0.86 | HDAC8 (0.61) | HDAC8HDAC6HDAC2ALDH1A1TSHR | |
| SCHEMBL8066345 | 0.86 | HDAC8 (0.61) | HDAC8HDAC6HDAC2ALDH1A1TSHR | |
| SCHEMBL2079073 | 0.86 | HDAC8 (0.61) | HDAC8HDAC6HDAC2ALDH1A1TSHR | |
| SCHEMBL23513227 | 0.83 | HDAC8 (0.59) | HDAC8HDAC6HDAC2ALDH1A1TSHR | |
| SCHEMBL23496820 | 0.83 | HDAC8 (0.59) | HDAC8HDAC6HDAC2ALDH1A1TSHR | |
| SCHEMBL16700836 | 0.83 | HDAC8 (0.58) | HDAC8HDAC6HDAC2ALDH1A1TSHR | |
| SCHEMBL23058167 | 0.83 | HDAC2 (0.58) | HDAC8HDAC6HDAC2ALDH1A1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006051410-A1 | AZABENZOXAZOLES FOR THE TREATMENT OF CNS DISORDERS | PFIZER INC. (US) | 2006-05-18 | — | — | WO | disclosed |