Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.61 |
| ▸ | GSK3A | P49840 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | STAT6 | P42226 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2079073 | 1.00 | HDAC8 (0.61) | HDAC8HDAC6HDAC2GSK3AGSK3B | |
| SCHEMBL8066345 | 1.00 | HDAC8 (0.61) | HDAC8HDAC6HDAC2GSK3AGSK3B | |
| SCHEMBL23496820 | 0.89 | HDAC8 (0.59) | HDAC8HDAC6HDAC2GSK3AGSK3B | |
| SCHEMBL23513227 | 0.89 | HDAC8 (0.59) | HDAC8HDAC6HDAC2GSK3AGSK3B | |
| SCHEMBL7057266 | 0.86 | HDAC8 (0.62) | HDAC8HDAC6HDAC2GSK3AGSK3B | |
| SCHEMBL6007674 | 0.86 | HDAC8 (0.62) | HDAC8HDAC6HDAC2GSK3AGSK3B | |
| SCHEMBL16700836 | 0.85 | HDAC8 (0.58) | HDAC8HDAC6HDAC2GSK3AGSK3B | |
| SCHEMBL23058167 | 0.85 | HDAC2 (0.58) | HDAC8HDAC6HDAC2GSK3AGSK3B | |
| SCHEMBL29164939 | 0.80 | HDAC2 (0.59) | HDAC8HDAC6HDAC2GSK3AGSK3B | |
| SCHEMBL5075725 | 0.80 | HDAC8 (0.79) | HDAC8HDAC6HDAC2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019215203-A1 | TETRACYCLIC HETEROARYL COMPOUNDS | ASTRAZENECA AB (SE) | 2019-11-14 | — | — | WO | disclosed |