Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 10/20 | 0.64 |
| ▸ | TOP2A | P11388 | 3/20 | 0.60 |
| ▸ | TOP2B | Q02880 | 3/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | AADAT | Q8N5Z0 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | ALB | P02768 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.50 |
| ▸ | TUBB | P07437 | 1/20 | 0.50 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.50 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.50 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.50 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.50 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.50 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30306157 | 1.00 | GSK3B (0.64) | GSK3BTOP2ATOP2BKDM4EKMT2A | |
| SCHEMBL6007712 | 1.00 | GSK3B (0.64) | GSK3BTOP2ATOP2BKDM4EKMT2A | |
| SCHEMBL4747750 | 0.91 | GSK3B (0.62) | GSK3BTOP2ATOP2BKDM4EKMT2A | |
| SCHEMBL1345510 | 0.91 | GSK3B (0.63) | GSK3BTOP2ATOP2BKDM4EKMT2A | |
| SCHEMBL12131053 | 0.91 | GSK3B (0.57) | GSK3BTOP2ATOP2BKDM4EKMT2A | |
| SCHEMBL12160738 | 0.91 | GSK3B (0.63) | GSK3BTOP2ATOP2BKDM4EKMT2A | |
| SCHEMBL9872970 | 0.89 | GSK3B (0.60) | GSK3BTOP2ATOP2BKDM4EKMT2A | |
| SCHEMBL26193679 | 0.88 | GSK3B (0.59) | GSK3BTOP2ATOP2BKDM4EKMT2A | |
| SCHEMBL26200350 | 0.88 | GSK3B (0.62) | GSK3BTOP2ATOP2BKDM4EKMT2A | |
| SCHEMBL9873852 | 0.87 | KDM4E (0.68) | GSK3BTOP2ATOP2BKDM4EKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0924213-B1 | PYRIDOBENZOXAZINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2006-06-28 | — | — | EP | disclosed |
| EP-1020459-B1 | CIS-DISUBSTITUTED AMINOCYCLOALKYL-PYRROLIDINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2005-04-06 | — | — | EP | disclosed |
| US-20020077345-A1 | Cis-substituted aminocycloalkylpyrrolidine derivatives | DAIICHI PHARMACEUTICAL CO., LTD. | 2002-06-20 | — | — | US | disclosed |
| US-6191129-B1 | MICROBIOCIDES, BACTERICIDES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-02-20 | — | — | US | disclosed |
| US-6184388-B1 | ANTIBACTERIAL AND ANTIMICROBIAL, QUINOLINE ANTIBIOTIC | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2001-02-06 | — | — | US | disclosed |
| US-6121285-A | 5-AMINO-7-(4-(1-AMINOCYCLOPROPYL-3-FLUORO-1-PYRROLIDINYL)-6 -FLUORO-1-(2-FLUORO-1-CYCLOPROPYL)-1,4-DIHYDRO-8-METHOXY-4-OXOQUINOLINE-3 -CARBOXYLIC ACID, FOR EXAMPLE; ANTIMICROBIAL DRUGS WITH HIGH SAFETY | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2000-09-19 | — | — | US | disclosed |
| EP-1020459-A1 | CIS-DISUBSTITUTED AMINOCYCLOALKYL-PYRROLIDINE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2000-07-19 | — | — | EP | disclosed |
| EP-0924213-A1 | PYRIDOBENZOXAZINE DERIVATIVES | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1999-06-23 | — | — | EP | disclosed |
| US-5097032-A | Quinoline- and naphthyridine carboxylic acids, salts | WARNER-LAMBERT COMPANY (US) | 1992-03-17 | — | — | US | disclosed |
| EP-0172651-B1 | Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids; substituted-5-amino-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds | WARNER-LAMBERT COMPANY (US) | 1990-02-07 | — | — | EP | disclosed |
| US-4822801-A | 4-oxo-1,4-dihydroquinoline-3-carboxylic acid derivative as antibacterial agents | WARNER-LAMBERT COMPANY (US) | 1989-04-18 | — | — | US | disclosed |
| EP-0172651-A1 | Substituted-9-fluoro-3-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acids; substituted-5-amino-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acids; substituted-5-amino-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acids; derivatives thereof; pharmaceutical compositions comprising the compounds; and processes for producing the compounds | WARNER-LAMBERT COMPANY (US) | 1986-02-26 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020077345-A1 | Cis-substituted aminocycloalkylpyrrolidine derivatives | Q6ZSR9, ARG1, ASNS | GSK3B 4856/4885TOP2A 492/4885TOP2B 905/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.