Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 7/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7886252 | 0.81 | CRHR1 (0.33) | CRHR1 | |
| SCHEMBL30278 | 0.80 | PDE10A (0.46) | CRHR1 | |
| SCHEMBL10238822 | 0.79 | CRHR1 (0.34) | CRHR1 | |
| SCHEMBL30183 | 0.79 | CRHR1 (0.33) | CRHR1 | |
| SCHEMBL10280617 | 0.79 | CRHR1 (0.33) | CRHR1 | |
| SCHEMBL597165 | 0.79 | CRHR1 (0.31) | CRHR1 | |
| SCHEMBL584441 | 0.78 | CRHR1 (0.32) | CRHR1 | |
| SCHEMBL30989 | 0.77 | CRHR1 (0.35) | CRHR1 | |
| SCHEMBL10239142 | 0.77 | CRHR1 (0.33) | CRHR1 | |
| SCHEMBL584907 | 0.77 | CRHR1 (0.33) | CRHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2417138-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | Schering Corporation (US) | 2012-02-15 | — | — | EP | disclosed |
| WO-2010118207-A1 | PYRAZOLO [1, 5-A] PYRIMIDINE DERIVATIVES AS MTOR INHIBITORS | SCHERING CORPORATION (US) | 2010-10-14 | — | — | WO | disclosed |