Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 12/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 12/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 12/20 | 0.41 |
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6007233 | 0.99 | CHRNB2 (0.41) | ALDH1A1HPGDL3MBTL1CHRNB2CHRNA7 | |
| SCHEMBL6008721 | 0.97 | CHRNA7 (0.41) | ALDH1A1HPGDL3MBTL1CHRNB2CHRNA7 | |
| SCHEMBL6009210 | 0.95 | CHRNA7 (0.42) | ALDH1A1HPGDCHRNB2CHRNA7CHRNA4 | |
| SCHEMBL6007342 | 0.92 | HRH4 (0.43) | ALDH1A1HPGDCHRNB2CHRNA7CHRNA4 | |
| SCHEMBL6008616 | 0.92 | CHRNA7 (0.40) | ALDH1A1HPGDCHRNB2CHRNA7CHRNA4 | |
| SCHEMBL6006391 | 0.91 | CHRNA7 (0.40) | ALDH1A1HPGDCHRNB2CHRNA7CHRNA4 | |
| SCHEMBL6007516 | 0.91 | CHRNA7 (0.40) | ALDH1A1HPGDCHRNB2CHRNA7CHRNA4 | |
| SCHEMBL6009276 | 0.88 | CHRNA7 (0.44) | CHRNB2CHRNA7CHRNA4HTR3AKCNH2 | |
| SCHEMBL6009260 | 0.88 | CHRNA7 (0.44) | CHRNB2CHRNA7CHRNA4HTR3AKCNH2 | |
| SCHEMBL6006543 | 0.86 | CHRNA7 (0.42) | CHRNB2CHRNA7CHRNA4HTR3AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067515-B2 | Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease | PFIZER INC. (US) | 2006-06-27 | — | — | US | claimed |
| US-20030045540-A1 | Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-03-06 | — | — | US | claimed |
| US-7067515-B2 | Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease | PFIZER INC. (US) | 2006-06-27 | — | — | US | disclosed |
| US-20030045540-A1 | Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease | PHARMACIA & UPJOHN COMPANY | 2003-03-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030045540-A1 | Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease | NQO2, SLC10A1, CYP7A1 | ALDH1A1 561/4885HPGD 613/4885L3MBTL1 2062/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.