Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOD1 | P00441 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | POLA1 | P09884 | 4/20 | 0.49 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ABHD16A | O95870 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12704636 | 1.00 | SOD1 (0.54) | SOD1CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL280128 | 0.85 | SOD1 (0.54) | SOD1CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL279978 | 0.85 | SOD1 (0.54) | SOD1CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL15604550 | 0.78 | SOD1 (0.56) | SOD1CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL15603505 | 0.74 | CYP3A4 (0.56) | SOD1CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL12887435 | 0.73 | SOD1 (0.48) | SOD1CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL280399 | 0.73 | SOD1 (0.48) | SOD1CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL15339315 | 0.73 | SOD1 (0.73) | SOD1CYP3A4MAPTMEN1KMT2A | |
| SCHEMBL24270695 | 0.71 | SOD1 (0.85) | SOD1POLA1NR1H2NR1H3 | |
| SCHEMBL20561073 | 0.71 | SOD1 (0.85) | SOD1POLA1NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912932-B1 | INTERLEUKIN-1 AND TUMOR NECROSIS FACTOR-A MODULATORS; SYNTHESES OF SUCH MODULATORS AND METHODS OF USING SUCH MODULATORS | NEREUS PHARMACEUTICALS INC (US) | 2012-05-02 | — | — | EP | disclosed |