Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | GMNN | O75496 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | STAT6 | P42226 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | SLC5A2 | P31639 | 13/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SLC5A1 | P13866 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8371823 | 1.00 | KDM4E (0.55) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL8367682 | 1.00 | KDM4E (0.55) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL8626628 | 0.90 | KDM4E (0.44) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL8134985 | 0.90 | KDM4E (0.44) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL8143290 | 0.90 | KDM4E (0.46) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL8184627 | 0.88 | KDM4E (0.47) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL15532111 | 0.88 | KDM4E (0.53) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL8175230 | 0.88 | KDM4E (0.53) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL8368995 | 0.88 | KDM4E (0.53) | KDM4EGMNNLMNAMAPTBLM | |
| SCHEMBL1000703 | 0.88 | KDM4E (0.53) | KDM4EGMNNLMNAMAPTBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1677784-A1 | INDOLE ANTIVIRAL COMPOSITIONS AND METHODS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005034943-A1 | INDOLE ANTIVIRAL COMPOSITIONS AND METHODS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2005-04-21 | — | — | WO | disclosed |
| WO-2004080466-A1 | CYTIDINE ANALOGS AND METHODS OF USE | RIBAPHARM INC. (US) | 2004-09-23 | — | — | WO | disclosed |
| EP-1019425-A1 | MODIFIED BENZIMIDAZOLE NUCLEOSIDES AS ANTIVIRAL AGENTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999051619-A1 | ARABINOFURANOSYL BENZIMIDAZOLES AS ANTIVIRAL AGENTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1999-10-14 | — | — | WO | disclosed |
| EP-0845001-A1 | 5'-SUBSTITUTED-RIBOFURANOSYL BENZIMIDAZOLES AS ANTIVIRAL AGENTS | The Regents of The University of Michigan (US) | 1998-06-03 | — | — | EP | disclosed |
| WO-1997027204-A1 | MODIFIED BENZIMIDAZOLE NUCLEOSIDES AS ANTIVIRAL AGENTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1997-07-31 | — | — | WO | disclosed |
| WO-1997007125-A1 | 5'-SUBSTITUTED-RIBOFURANOSYL BENZIMIDAZOLES AS ANTIVIRAL AGENTS | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1997-02-27 | — | — | WO | disclosed |