Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 17/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 12/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 12/20 | 0.39 |
| ▸ | HTR3A | P46098 | 4/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.37 |
| ▸ | HTR3B | O95264 | 1/20 | 0.37 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.37 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6007849 | 0.93 | CHRNA7 (0.38) | CHRNA7CHRNB2CHRNA4HTR3AHTR3E | |
| SCHEMBL6008956 | 0.93 | CHRNA7 (0.37) | CHRNA7CHRNB2CHRNA4HTR3AHTR3E | |
| SCHEMBL6008858 | 0.85 | CHRNA7 (0.39) | CHRNA7CHRNB2CHRNA4HTR3AHTR3E | |
| SCHEMBL6009255 | 0.83 | CHRNA7 (0.57) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6007497 | 0.83 | CHRNA7 (0.39) | CHRNA7CHRNB2CHRNA4HTR3AHTR3E | |
| SCHEMBL6008666 | 0.83 | CHRNA7 (0.37) | CHRNA7CHRNB2CHRNA4HTR3AHTR3E | |
| SCHEMBL6006569 | 0.82 | CHRNA7 (0.41) | CHRNA7CHRNB2CHRNA4HTR3AHTR3E | |
| SCHEMBL6008218 | 0.80 | CHRNA7 (0.44) | CHRNA7CHRNB2CHRNA4HTR3AHTR3E | |
| SCHEMBL7231620 | 0.80 | CHRNA7 (0.43) | CHRNA7CHRNB2CHRNA4HTR3AHTR3E | |
| SCHEMBL6009277 | 0.79 | CHRNA7 (0.41) | CHRNA7CHRNB2CHRNA4HTR3AHTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067515-B2 | Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease | PFIZER INC. (US) | 2006-06-27 | — | — | US | claimed |