Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 9/20 | 0.57 |
| ▸ | HTR3A | P46098 | 9/20 | 0.57 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.57 |
| ▸ | HTR3B | O95264 | 4/20 | 0.57 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.57 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.57 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6008912 | 0.92 | HTR3A (0.54) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6008903 | 0.92 | HTR3A (0.54) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6008824 | 0.86 | CHRNA7 (0.53) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6008979 | 0.83 | CHRNA7 (0.39) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6007771 | 0.82 | CHRNA7 (0.56) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6007435 | 0.82 | CHRNA7 (0.56) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6009247 | 0.81 | CHRNA7 (0.50) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL5704884 | 0.78 | HTR3A (0.69) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6005921 | 0.78 | HTR3A (0.69) | CHRNA7HTR3AHTR3EHTR3BHTR3D | |
| SCHEMBL6006100 | 0.78 | HTR3A (0.57) | CHRNA7HTR3AHTR3EHTR3BHTR3D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7067515-B2 | Quinuclidines-substituted-multi-cyclic-heteroaryls for the treatment of disease | PFIZER INC. (US) | 2006-06-27 | — | — | US | claimed |