Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | PKM | P14618 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CBFB | Q13951 | 13/20 | 0.35 |
| ▸ | METAP2 | P50579 | 7/20 | 0.35 |
| ▸ | METAP1 | P53582 | 6/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.33 |
| ▸ | STAT1 | P42224 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3522525 | 0.85 | CBFB (0.40) | NPC1LMNAPKMRAB9ASMN1; SMN2 | |
| SCHEMBL31392583 | 0.84 | CBFB (0.46) | NPC1LMNAPKMRAB9ASMN1; SMN2 | |
| SCHEMBL9582382 | 0.84 | NPC1 (0.44) | NPC1LMNAPKMRAB9ASMN1; SMN2 | |
| SCHEMBL29617559 | 0.83 | CBFB (0.35) | NPC1LMNAPKMRAB9ASMN1; SMN2 | |
| SCHEMBL28595716 | 0.83 | CBFB (0.35) | NPC1LMNAPKMRAB9ASMN1; SMN2 | |
| SCHEMBL9960466 | 0.82 | STAT3 (0.33) | KDM4ESTAT3STAT1NPSR1 | |
| SCHEMBL6009229 | 0.81 | STAT3 (0.45) | NPC1LMNAPKMRAB9ASMN1; SMN2 | |
| Dipyridyl SCHEMBL28212071 | 0.78 | METAP1 (0.50) | NPC1LMNAPKMRAB9ASMN1; SMN2 | |
| SCHEMBL28347682 | 0.78 | CBFB (0.44) | NPC1LMNAPKMRAB9ASMN1; SMN2 | |
| Dipyridyl SCHEMBL5810894 | 0.77 | METAP1 (0.48) | NPC1LMNAPKMRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513537-A4 | SUBSTITUTED PORPHYRINS | UNIV DUKE (US) | 2006-09-06 | — | — | EP | disclosed |
| EP-1513537-A1 | SUBSTITUTED PORPHYRINS | DUKE UNIVERSITY (US) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003103680-A1 | SUBSTITUTED PORPHYRINS | DUKE UNIVERSITY (US) | 2003-12-18 | — | — | WO | disclosed |