Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
| ▸ | STAT1 | P42224 | 1/20 | 0.45 |
| ▸ | CBFB | Q13951 | 11/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | NPC1 | O15118 | 4/20 | 0.32 |
| ▸ | RAB9A | P51151 | 4/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | LMNA | P02545 | 3/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 6/20 | 0.32 |
| ▸ | METAP1 | P53582 | 6/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9582368 | 0.87 | STAT3 (0.57) | STAT3STAT1CBFBKDM4ENPC1 | |
| SCHEMBL3522520 | 0.86 | STAT3 (0.47) | STAT3STAT1CBFBKDM4ENPC1 | |
| SCHEMBL9960467 | 0.85 | STAT3 (0.42) | STAT3STAT1 | |
| SCHEMBL460724 | 0.83 | STAT3 (0.59) | STAT3STAT1CBFBKDM4ENPC1 | |
| SCHEMBL3509631 | 0.82 | STAT3 (0.44) | STAT3STAT1 | |
| SCHEMBL6009235 | 0.81 | NPC1 (0.35) | STAT3STAT1CBFBKDM4ENPC1 | |
| SCHEMBL3518268 | 0.77 | STAT3 (0.43) | STAT3STAT1CBFBKDM4ENPC1 | |
| Acetoacetic Acid SCHEMBL9748613 | 0.73 | STAT3 (0.48) | STAT3STAT1CBFBKDM4ENPC1 | |
| SCHEMBL432185 | 0.72 | KDM4E (0.46) | KDM4ENPC1RAB9ASMN1; SMN2LMNA | |
| SCHEMBL29822398 | 0.72 | KDM4E (0.46) | KDM4ENPC1RAB9ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513537-A4 | SUBSTITUTED PORPHYRINS | UNIV DUKE (US) | 2006-09-06 | — | — | EP | disclosed |
| EP-1513537-A1 | SUBSTITUTED PORPHYRINS | DUKE UNIVERSITY (US) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003103680-A1 | SUBSTITUTED PORPHYRINS | DUKE UNIVERSITY (US) | 2003-12-18 | — | — | WO | disclosed |